I've been using the 22/250 and the Swift for 43 years on deer, antelope, black bear and elk. Prior to this last year I've just used standard 14 twist barrels and 55-63 grain bullets.
I've mainly used standard cup n core bullets, found them to kill quicker than the preme bullets. We've a string of 30 one shot kills from 35 yards to 400 yards using the 60 Horn HP. Only two of them went anywhere the others went straight down! The two that went anywhere were a small whitey doe at 120 yards that took a 35 or so yard sprint and a muley buck at 35 yards that took a big hop and fell off a mountain.
This last year I had a 22/250 AI with 8 twist put together just so I can shoot the heavier bullets a bit.
The 22 CM is a wonderful round and incredibly capable as well as the other large 22's. The rigs are giant killers for sure!