I am not sure I want to answer that question lol .Trying to determine what percentage of opinions on .22 centerfires on medium and large game are based on actual experience doing so vs conjecture or intuition.
Definitions:
Good shot placement: putting a bullet through heart and/or both lungs.
Good bullet: said bullet will penetrate to reach heart and/or lungs with adequate expansion to disrupt function of said organs.
A 22 is a very deadly round and can kill lots of large things. It's all about bullet placement meaning head shots only.
Oops I miss read, I didn't see the centerfire part, my comment is for rim fire