Skip, that's a tough question, and even though I'm a proud 220 swift owner ,I'm not that silly to put the 22-250 down . If you had the greatest gunsmith make both rifles exactly the same , bbls,actions, stocks , scopes & triggers and had the best benchrest shooter shoot them ,but had the identity of the cartridges hidden, then you'd have to get a great reloader to hand load for each . Then you'd get one of two answers, either a tie,Or one would edge the other slightly. For the record the Swift is not a barrel burner, shoot a 22 rim-fire long and fast enough and it will do just that , but let's let Common sense prevail and the truth stand , Cheers!!!.