I used Remington factory loaded ammunition with the 55grn soft point last season to down a black tail. Fairly acurate in my Tikka T3 lite, groups hovered arround an inch, some better some worse(but not much). I used it because I KNOW(I'm comfortable with it) where the bullet will go when I squeese the trigger, where I was hunting there were no shot opportunities greater than 120 yards, and I didn't have a more suitable rifle to take. One shot squarely through both lungs and out the other side made him dead and you don't get more dead than dead. That said I did step it up to a 30-06 this year as I was forced to hold a shot earlier that morning on a magnificent fat necked buck due to a slight ammount of brush. Would the 22-250 have made it through the few twigs? Maybe, I think so but I think it is my responsibility to know before my finger touches a round off. The 06 would have no problems and that buck might be a bit bigger by fall.