We have used the 215 Hyb on several elk with fantastic results. Nothing has ever gone more than 40 yards, with 8 of 10 dropping at the shot. From 50ish to well over 800 yards. I have only recovered one 215 Hyb. Under the offside skin of a big bull. 432 yards, uphill, smashed both shoulders and shattered a vertebrae before coming to rest under the skin. Retained about 40% weight still. Jacket and remaining lead core stayed mostly together.
I use Hybrids (and other "match" bullets) on most game in almost every rifle I own.
.224 69 SMK
6mm 105 Hyb
.257 131 Blackjack (hope to use this on pronghorn this year)
6.5mm 130 OTM
6.5mm 140 Hyb (hope to try the 144 Hyb this year)
6.5mm 142 & 150 SMK
7mm 180 & 184 Hyb
7mm 183 SMK
.308 175 & 210 SMK
.308 215 & 230 Hyb
I have only recovered 4 bullets total.
.308 175 SMK @ 3300fps from 160 yard broadside bedded bull elk. Flopped over dead. Bullet was lost in the field, but probably around 50% retention?
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.308 215 Hyb @ 3100fps from 437 yard broadside bull elk. Dropped at the shot, kicked twice, then dead. Bullet was shredded. 40% retention, 88gr.
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6.5mm 130 OTM @ 2901fps from a 454 yard hard quartering away mule deer buck. Dropped without a twitch. Mushroomed well. 55% retention, 69gr.
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6mm 105 Hyb @ 3101fps, 450ish yards broadside pronghorn buck, dropped dead without a twitch. Perfect mushroom. 50% retention, 51gr.
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To be honest, the two slowest killing bullets I have seen were the 6.5mm 127 LRX @ 3009fps @ 530 yards on a deer, and a .308 210 HVLD @ 2950fps @ 250 yards on an elk. Shots were both well placed, and game appeared down, but both needed a follow up shot once we got to the animals.
Animals can be tough. Bullets can fail. But, in MY opinion, blaming bullets failure is a crutch 95% of the time for bad shot placement, ESPECIALLY when game is not recovered. I have heard several stories from people I know that have had issues with the 210 HVLD. One guy got 4 or 5 shots into a bull elk over a couple hours and miles of trailing. All shots were well placed.