Using the Berger 210 VLDH, I've shot one deer (~150lb) at 82 yards. Bullet penetrated all the way thru, with no evidence of coming apart. Impact was center ribs behind shoulder, slightly quartering towards me. Exit was ribcage opposite side, middle. The buck dropped at the shot. Loading him on the game cart revealed a broken back.
I also shot a 150-175 lb hog with the same load at ~50-60 yards. Impact was behind shoulder on a broadside hog. Exit was in three places offside. This bullet cleary came apart, but left a gaping hole on the rearmost exit, which was the left rear ham, a pencil size exit directly opposite the impact, and a good size hole in front of the shoulder, actually exiting behind the off-side ear.
My muzzle velocity is 3144 FPS instrumental at 18 feet (~3149.9 at the muzzle).