I just talked to Tim at Hornady. He actually mentioned a guy with a 28 nosler trying to push them over 3200fps that was having problems (who could that be). Said they weren't really intended for that velocity, lol. If that's their position, they should probably say as much, but I know people are making them work even faster.
In any case, he also said a barrel with cut rifling in it's early stages can damage the bullet at high velocities due to the sharper edges of the rifling. He said in every case in their testing, over time the barrel was able to shoot them after the rifling became "bullet lapped". He mentioned hand lapping will likely fix this. Further, a hot barrel with these conditions will obviously tighten up and cause further damage during shooting.
I'm going to bore scope the thing to make sure there aren't any glaring defects. I don't really care to shoot my barrel half out to make these work, but I'll probably use up what I have left at the lower velocities that work, and see if it works higher in a couple hundred more rounds.