I've used them out of my 28 Nosler. Beware Most people call them HamBurgers. My first experience was at 100 yards on a mule deer buck, the bullet blew up on its neck only about 1" of penetration. knocked him down but had to kill him after. Second was on a bull at 256 yards broad side. It him right in the center of the shoulder, again failed blow up of the bullet only breaking the surface of the skin. Second round hit a rib again with the bullet blowing up. I managed to kill the bull with an ELDX bullet I had. I asked the guy who loads for me about them and he's had nothing but trouble from his clients with it. Moved to the Hammer Hunter 4 for 4 on elk one shot. The burgers do outshoot the Hammers on plates, but I will never use them on an animal.