I am a huge fan of Max. Point Blank Range for Hunting. I do enjoy dialing when having fun on steel at the farm. But hunting I go with MPBR....here's a good example why:
I went on my first elk hunt outside of Cody, Wyoming with an outfitter (I'm from Virginia and have grown up hunting waterfowl and whitetail). To prepare I zeroed my rifle (a Nosler 280AI with a Leica 2-10x50) using the Maximum Point Blank Range method. My rifle was zero'd at 260 yards so anything up to 350 was within a 9" circle. Perfect for an elk's kill zone. My feeble mind can't waste time counting MOA's or calculating under pressure for a quick shot nor do I want to shoot an animal over 400 – 500 yards anyway based on my skills (hardly ever have over 200 yd shots in VA anyway). I was with a great friend of mine and a couple guys he knows (I don't) from previous trips out west. My buddy tagged out a couple days before this event so I was hunting with our guide and one of the other guys. We were sitting on a rock face about 400-500' above the lower fork of the Shoshone River watching a group of elk filter through a funnel down to the river bed. It was an amazing spot.
Long story short(ish) I was playing backup to this guy because he won the coin toss to shoot first that day. He was laying prone on the edge of this rock face looking down over the elk. He had this bull dead to rights at 225 yards as it came through the willows on the river bed. He had his scope dialed to 20 and was waiting for a good shot (way too much magnification for the distance). He kept tinkering with his scope for ranges on his turrets and questioning himself. For 30 minutes the bull thrashed willows and wouldn't step out or present a broadside shot. My rifle was laying on my pack about 2' to his right loaded and ready to go in the event I had to back him up. The agreement was if he hit it he would put a second round in if necessary. If it were a clean miss I would be free to shoot so the bull didn't get away.
A shot from up river boomed from another hunter in our group somewhere and the bull and his herd took off (running from our left to right). My buddy shot hurriedly and it was a clean miss. He then yelled he couldn't find it in the scope (because he was dialed in so much). I was sitting on a rock behind his feet to video his shot approximately 6' away from my rifle. I quickly dropped my phone and ran to my rifle. I was standing as I picked my rifle up. From a freehand position I found the elk (scope was on 2 power), found the shoulder, put the crosshairs on it and let it fly. I hit just behind the shoulder penetrating both lungs.
The bull stopped dead in his tracks from a full run. I racked another round in and hit him again and he fell over dead as a hammer. I ranged him at 300 yards as he lay dead. I'm certain the first shot was lethal but everyone told me shoot until they fall. I turned to the guide and asked what the heck just happened! It was unbelievable. My buddy was laying on the ground in disbelief. I was standing there in disbelief. The guide gave me a wink of approval as he didn't want to celebrate too much considering one guy was crushed and I was ecstatic.