This is a dangerous thread!!! Curse the necromancer who resurrected it !!!! (just kidding there.....).
I'm still sorting out my 7mm-300 Win mag, but have long given thought to a big, fat 338 and this is kindling a fire I just do not have the time for! I sure look long and hard at the 338-378 Weatherby... The hoola-hoop around her ankles doesn't bother me a bit 'cause she's among the fastest in her class....
For me, I like a small 7mm, a big-ish 7mm, and a BIG 338! To me, unless you want a one-gun armory, (overkill for smaller game, but maybe a wee bit anemic for bigger stuff wayyyyyy out there), I really prefer to skip over the .30 caliber.
That said, the 300 Win mag is pretty tough knock - it really is pretty close to a perfect, one-gun armory. However, I'm just sweet on the 7mm's and a big 7mm will do almost everything a big .30 cal will. If I need more, a truly big 338 just solves the problem with no muss - no fuss.
Hats off to the mighty 338-378 W-by!!!!