If you drew a line from the 1 to the 5 and the 2 to the 4, I would want to place my bullet in the center of the X.
I shoot a .260 ackley with a 140 vld at 3070, that would give me the most room for error at longer ranges, and would be a nice center lung/possibly top of heart shot. It would also depend on wind direction and how confident I was in my wind call...I have shot animals with this gun from 440 yards to 925 yards.
If I was closer and didnt need as much room for error, I may place my bullet a little higher in an attempt to have impact shock closer to the spine drop him on the spot. If I had to pick one number though....it would be 5.