I am not to recoil sensitive. I own everything from a 22 to a 460 wby. The Weatherby even with a break will wake you up in the morning but you need to focus on the target not the rifle, pick a spot and let it float, follow through. Good bone on bone form and letting the rifle rest in the pocket of the shoulder will help absorb some of the recoil. Square up and step into it. Even then it is going to feel like someone slapped the **** out of you. It is fast and sharp but if your ready you can handle it. Stock design matters a lot. I load the 460 down to 458 Lott levels and I don't shoot it a lot, especially at more than $5 a pop with hand loads and $10 with factory loads. But a few shots here and there doesn't bother me to much. It is kind of fun and on game you don't hardly notice it, but that comes from learning to shoot well with a lesser cartridge. If I were a new shooter preparing for a dangerous game hunt, which is really the only reason to own one of these behemoths, I wouldn't start with a 460. My go to rifles for almost everything are a 6.5 lbs 308 and a 6.75 lbs 270 win. Big fan of the 300 win mag too but I prefer them in a 9lbs rifle.
When it comes to managing recoil, form and the construction and weight of the rifle matter. I would not shoot the 460 prone or off a bench free bore. A good set of shooting sticks from the standing position is the way it is meant to be shot and when you do hold on but don't focus on holding on!
Learn good form and proper technique and you can shoot just about anything once or twice. To those of us getting older I concur that I don't enjoy it as much as I did when I was a young man but I still like to ride the thunder every now and then. And if Capes or Big browns are on the menu I don't want anything less than a 338 win mag or 375 H&H in my hand. Hoping for one of those two in the near future. Once you shoot a big bore or 3.5 inch magnum everything else will feel like child's play.
Note: the 416s and up aren't play toys for the faint at heart. The recoil on some of them can give you a heart attack, literally. Make sure you get proper instructions on how to use it and that the rifle fits you. And if if weighs less than 9-10lbs run! Whoever built it was an idiot!
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