Following the calcs of "overbore" - case capacity in grains of water divided by the area of the bore cross section in square inches, I would say my current 22-250AI, the past 22-06 and my old 25-7mmRM.
Since I still use the 22-250AI's, yes, I would do those again, but the 22-06 gave little gains over the 22-250AI and nothing over the 22-243 versions. The old 25-7mmRM was on par with a 257 Wby but without the double radius shoulder and cheaper and more plentiful brass.
Forgot, I did shoot a 50BMG for a few years, so there it that too.
Since I still use the 22-250AI's, yes, I would do those again, but the 22-06 gave little gains over the 22-250AI and nothing over the 22-243 versions. The old 25-7mmRM was on par with a 257 Wby but without the double radius shoulder and cheaper and more plentiful brass.
Forgot, I did shoot a 50BMG for a few years, so there it that too.
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