Wonderful round and rifle with mixed reputations. I've had a Mk V in .300 since 1987 and it was my one-gun do-it-all rig until a few years ago. The stock developed a little crack behind the receiver a couple of years after I got it and the factory replaced it for free with a gorgeous piece of wood. It's been to many states and Africa a bunch of times. I put more than 1000 rounds through it in the years around my first trips to Africa. It finally got re-barreled from 1:12 to 1:10 and re-blued at the factory and it's as good as ever. They looked it up and the gun (well, what's left of the original gun) is almost as old as me.
It likes 180gr TTSX bullets with H4831-SC and 215GMs. When I'm on my game it will do 1/2" at 100 yards all day long and it will bang steel to 1000 yards. IIRC, it has something like 0.325" of freebore! The thin barrel heats up darn quickly so 5-shot groups never look great. This gun has piled up tons and tons of game for me. The trigger isn't great, the thing wallops like a mule, and it's darn loud, but it hits hard enough to pile up moose, eland, and zebras. Weatherbys were good with Partitions, but they really came into their own with the advent of better bullets that handle the velocity.
Guides and PHs don't always like it. After really, really learning how to shoot it well I'm convinced many (most?) people just don't shoot magnums well. Nothing on earth will make up for poor shot placement and sadly the Bees have a reputation for making people shoot poorly.
After some shoulder issues I switched to a custom build .300 Win Mag with a 5" suppressor and I've never looked back. That thing is like some sort of recoil-reducing, noise reducing voodoo magic. I would have put the can on the .300 Wby, but it deserves to have clean lines and stay how it has always been. Have fun with it, shoot straight, and bring a sharp knife.