Long Time Long Ranger
Well-Known Member
My best load with the 225 grain bullet in a 338-378 wby with a 28" Hart barrel is 128 grains of H-870 at 3440 fps. This is a 225 accubond. Since you can't get H-870 any more try Retumbo. Powders faster than that will get max pressure before you hit top velocity. I wouldn't go faster than H-1000. The 338-378 is better with bullets over 200 grains. The 225 Barnes may not open well on little whitetails. The accubonds may be better for that purpose. My brother got a nice mule deer at 650 yards hunting with me last year shooting the 225 ttsx out of his 338-300 RUM I built for him. The 225 performed very well on that deer so it may work but that would be way less velocity than the 338-378 shooting close range smaller whitetails.