What are you planning on shooting at at a 1000 or more yards? Most high power, long range shooters I know recommend going to a 200 gr bullet for 1000 or 1000+ shooting, as it retains velocity better. I know one guy who's using 250gr bullets. These folks are hard butt shooters out to win. I was advised to use 190s in my 308 Winchester (not mag), since the lighter bullets tend to lose velocity too fast, and though a mag probably wouldn't , can go subsonic at a 1000 yds. Only have to get the 190s moving about 2550 to stay sonic at a 1000 yds (if a bullet goes subsonic, that is drops below speed of sound, it will often become unstable, start to yaw, and go off target altogether).
There is a standard rule of thumb for how far to come up with almost and ammo. It's called the 2,2, 3,3 4,4, etc rule. from 100 you need to come up 2 moa, to be on at a 200, 2 more to be on at 300, then 3 more to be on at 400, and so forth. for my 308, I need 39 minutes of elevation to be on at a 1,000 yds, and this is probably pretty close for most rounds, though might be a bit less for a Win Mag, but not really that much less. There are targets sold that allow you to sight in your rifle for a 1000 yds, at 50 yds (and fine tune it at a 1,000 yds). Also, using this target, which is actually made for using the 06/308, you could then "check" your dots to see where they are at. Set the main cross hair at say 500, then aim where your need to on the target, with the next dot and see where you're hitting. Might find that using you main poa as 500 then the next dot would give you 600. But if not, once you've determined how far you have to come up at each yardage, put it on a piece of tape and glue it to your rifle for reference.
I think Sierra has a routine on their web site about breaking in a barrel. Some barrels are lapped to begin with , so might not foul from day one, while others, might be rough and foul for 50 shots or more. Basically, the routine is, fire a shot, thoroughly clean the barrel, fire another one, throughly clean the barrel, fire another, and so on, for 5-6 rounds, then fire 2 for another half dozen firings. Best thing in the world right now for cleaning a barrel where fouling might be, is Wipe Out. Spray it in, let it set a few minutes and wipe it out. Will definitely take the copper out. Can be gotten from MidWay. I've quit using anything else.
If you've been shooting awhile and still getting fouling, go to Corbin swage companies web site and they have a product that you can put on a tight patch and it'll scrub stuff real aggressively, and another that will LAP the barrel. Might also want to look at Midway for the Dave Tubb fire lapping set up which has bullets enbedded with different amounts of grit. Fire the set through the barrel, in order, and should have all the roughness out.