I actually reload 180g TSX's for my 300 RUM, I shot a forkie sausage deer this past weekend at around 75yard, I had an odd angle, right in threw the new and exit wound was still about golfball sized through the ribcage, but practically no meat other then the ribcage was ruined. My friend also reloads 180 TSX's for his 300 Wby, nailed his at around 200 yards and very minimal damage compared to what I'd expect. They have my vote of confidence on any game and won't ruin meat unless you get expansion and hit a bad spot! I say this because my buddy shot another deer at around 450 yards this season so far and nailed him square on the middle of the back and broke his spine and destroyed most the backstraps. As long as you're careful with the shot you wont ruin too much meat because these bullets will expand fast and hold their weight.