Yes! There is always an issue most of the time when the wrong cartridge is fired in the wrong firearm. Exceptions are .22 shorts and longs in a .22LR, 38 Special in a .357 magnum, .44 Special in a .44 Magnum, and a few others that are all straight wall cartridges that all have the same diameter case and headspace.Would there be any issue shooting 6.5x55 ammo though a 6.5 creedmoor rifle?