I should clarify as I kind of skipped over the first part of my load dev.. My step 1 is finding max pressure, so I work up powder charges, one shot each, in .3 or .5 grain (depending on case capacity) increments and shoot each over a chrono until I see pressure signs and then call that max.
Then I graph the chrono data to see if there's a flat spot in the velocity and do my seat depth test in the middle of that.
After the seat depth test, then I shoot a real ladder test at 300 yds. The nodes sometimes line up with the chrono data, sometimes not. the crono data is limited sample size so I am only using it as a baseline.
It's kind of a back and forth as each variable effects the other like Jud said, but the seat depth is definitely the more "coarse" of the two.