DF....I was afraid to post my sentiments that mirror yours, with so much support for the .243 here. I have successfully shot a .243 on deer for most of my life. I am a real good shot, and even with the .243, every deer I have ever shot never traveled more than ten feet...BUT THEY ARE STILL KICKING AND IN PAIN! I always go for a second shot to end any suffering, but that has certain problems. So for the last five years, I decided to hunt with a Savage Light Weight Hunter (5.5 lb.) 6.5 Creedmoor. It has solved the problem of a "one shot kill" for me very well. So I am here to cast a vote for just a little more "umph" than the .243 provides if the wife can handle just a tiny bit more recoil.