The odd time a solution presents itself. I used to load and shoot 8x57. I meticulously researched and tested all the powders available at the time. Then I met a 8x57 "expert" and he said his best loads were simply scooping 4350 into the case, level with the top, and compressing the load with the mid-weight bullet. My manuals did not indicate catastrophic pressure so I experimented, starting with scooped powder below the case neck, and adding powder until it filled to the top. Absolutely the best accuracy in my rifle. I dumped a number of full cases onto my scale and there was some variability. I'm guessing the fact of consistency of case fill benefitted more than variations in powder weight hindered. Of course I monitored cases by brand, neck thickness, capacity, etc.