Always a fun and entertaining discussion... for me the bottom line on this is use what you're most proficient with. Seriously, drop the ego, and use what you have the most chance of success, hence surviving with.
IMO, there's a very small percentage of the hunters out there that truly possess the skills, cool and calm needed to effectively protect themselves via a handgun (and in a lot of cases with a long gun). That's not a dig, but it's a fact.
I know a lot of guys who carry a handgun and yet they rarely ever fire it, let alone practice bringing it to action from a holster in a nanno! That's a major part of the reason I encourage people to consider spray over a handgun. The spray will give most people the best chest to deploy and survive with.
Whichever one chooses, just be sure to have it at easy access, not covered up. In regards to the spray, I worked with it a bit last spring and found I could leave it in the UDAP holster, on my packs belt and put it to action while in the holster using my left hand.
That said, I carry a handgun, for the most part it's a Glock 10 in a Kenai Gunslinger chest holster. I'm comfy with the outfit, and I can skin it and get it into action now.
Whichever you use, practice a ton with it, don't be that guy that shoots 50 rounds a year at the range and feels like he's ready to rock.
Just a thunk