In my experience with .308 Winchester and .338 Lapua Magnum your 100-yard zero will NOT change.
Where you are going to find variance is in the amount of drop you will have at your extended distances at altitude due to thinner air density.
You will gain about 25 to 45/50 feet per second in muzzle velocity per 1,000 feet of elevation -- the equivalent of another inch of barrel length. You won't need to dial in as much elevation correction the higher you go.
My experience is based on transitions between near sea level (San Joaquin Valley in California; Fort Lewis, Washington; Fort Bragg and Camp Butner, North Carolina) to ranges at altitude (4,500-5,000 feet at Dugway Proving Ground, Utah; Rexburg, Idaho; Rio Rancho, New Mexico; Bozeman, Montana; 6,000 feet at Park City, Utah, and 6,680 feet at Raton, New Mexico; and 10,000 feet in the Uinta Mountains in Utah).
Where you are going to find variance is in the amount of drop you will have at your extended distances at altitude due to thinner air density.
You will gain about 25 to 45/50 feet per second in muzzle velocity per 1,000 feet of elevation -- the equivalent of another inch of barrel length. You won't need to dial in as much elevation correction the higher you go.
My experience is based on transitions between near sea level (San Joaquin Valley in California; Fort Lewis, Washington; Fort Bragg and Camp Butner, North Carolina) to ranges at altitude (4,500-5,000 feet at Dugway Proving Ground, Utah; Rexburg, Idaho; Rio Rancho, New Mexico; Bozeman, Montana; 6,000 feet at Park City, Utah, and 6,680 feet at Raton, New Mexico; and 10,000 feet in the Uinta Mountains in Utah).