I have been running QL since 2010 with excellent results. Early on I was also having difficulty getting it tuned. Both the original developer and the ballistician at Western powders weighed in and helped me out. Each new combination of components needs to be tweaked. It's not a one and done process, nor do I think having "friends" model a load for you, is a good idea, unless you give them a reasonable amount of load/velocity data and all your cartridge and rifle specifics, AND they know what they are doing. I did my master's thesis on ballistics modeling, so I understand how to run a model. This is a model. I do not claim to be an expert either. So do what is right/safe for you - not what some "expert" said on the interwebs! Having said that. Here is what I do - for every unique combination of components/rifle AND every change in powder lot.
Start with actual COL, barrel length, bore cross sectional area (usually only necessary if you are having difficulty getting good results). Load 5 shells of your intended components in .5g powder increments, within the published max powder charge. Get velocities from a Labradar or magneto speed, preferred. Tweek the case capacity value down if your real velocity is faster than the model, up if the model is showing faster velocity than reality. I typically stop tweeking case capacity after I get ~5% from measured case capacity and move on to shot start/initiation pressure if I am still not matched up.
Next I tweek the shot start/initiation psi variable up if I still need to speed up the model, and vice versa.
At the time I was told that the shot start/initiation value in QL was not a measured value, but a starting point largely based on bullet design. Mono bullets were using an un-grooved assumption, so likely newer TSX, TTSX, LRX designs the shot start pressure can be lowered to get your model to be accurate.
That was the process provided by the ballistician at Western, who used QL extensively for load development then measured the results in a pressure barrel. I was told to be mindful of the pressure = velocity equation. You can't have one without the other. If QL says you are at 65,000 psi at 3100 fps - believe it!