I have been hand loading for 40 years and I have probably used most makes of primers. Like someone else said I use the primer that best suits the load. But if I had to choose just one standard and one mag primer they would be CCI BR2 and CCI 250s. If it came down to just being able to have only one primer it probably would be CCI 250. In all these years and probably a million or more rounds loaded and shot I have only had two experiences with fail to fire or hang fire. Both were not the primers fault. One was a shotgun shell that had a carboard base in it that I picked up in a dove field after they had been in the rain. One of these shells hang fired with a POOF and the shot cup and shot just barely made it out of the barrel. No doubt wad retained some moisture and degraded powder. Other time it was me not seating the new to me WOLF primers. They were just a hair larger round and you really had to put some pressure on the seating to get them to go flush in the primer pocket. Once I learn this no problems. I sure wish I could get some more of the WOLF primers. Best primers I ever tried in all sizes. I still have a few put back for certain established loads for certain firearms.