I have no doubt that it depends greatly upon lot number of primers and powder, as well as the type of powder, but I tried using CCI-250 in 375CT with Retumbo and one to two out of every 3 were hang fires. I know it isn't the components, since I used that same lot of both primers and powder in 338LM with no ill results at all. Imagine my surprise!
When I went researching as to why it was happening, I encountered about half a dozen people that were very familiar with the problem. They gave me the "you new or something?" look. The big cartridges are a different animal than the 338's.
Your experiences would seem to indicate that RL-33 is quite a bit easier to ignite than Retumbo.