I've also had this same velocity change happen in the past. Recently I learned something about my current "Jeckle & Hyde" velocity. After I had arrived at a load that would generally group well, I decided to try the 10 round Satterlee test. I loaded up a series of shots spaced 0.2 grain apart. What I discovered is the powder charge I had chosen for my load was in an unstable velocity node. It was a velocity flat spot but the center velocity actually dropped in the middle and then came up again on the next step. ( I used a magnetospeed )
There was another velocity flat spot in the series so I'm currently trying it out. On three different occasions I've loaded some rounds, gone out to the range, and measured velocity and shot a couple groups. The average velocity from each of those three outings is within 5 fps of each other, and all the SD are single digit.