I own a few of each and use them for hunting, target, and lots of 200-300 yard egg shoots every year.... good test for a scope especially with a lot of mirage. Generally, both are excellent scopes and you should not go wrong with either. If weight is a factor in the hunt, you will save about a pound and some bulk with the Leupold MK4. I like the positive clicks on the Nightforce NXS but the trade off is 10 MOA per revolution compared to 15 with the Leupold. If cost is a factor you usually pay 20-30% less for the comparable LP in the states. It may be my eyes but the LP seems to have a little more color/contrast then the NF. I have had really good long range results with both......tough call.