If you want to find em when you kill em just shoot em right. Both cartridges are more than adequate if you take shots you know you can make. If you are going to lug around a full length action then why stop at 280 Rem? Go with the 33 Nosler and be done with it. 225 grain Accubonds for everything. Simple. Cool. Still sexy. You still have to figure wind, distance, and elevation angle and make an accurate shot. Why carry all that? If you do your job the PRC is perfect. If you can't do your job, no cartridge is adequate.