"Yes, a 225 or 250 will kill anything in North America, but a 300 will do it with less wind drift, more energy and more impact velocity at extended ranges."
I believe you should have said "VERY extended ranges", run the numbers at actual hunting distances, say 1200 yards and less. You'll see why they still make the lighter .338's, they are quite a bit faster and quite a bit flatter, with only minimal wind difference at all but the farthest ranges, where most guns can't shoot tight enough groups to hit at even in theory. And the difference in recoil is very noticeable.
With all that said, I would say take a hard look at the 265 before you jump to the 300's, just my opinion.