H4350 works pretty well with Nosler 55 Tipped Varmageddons in my rifle. My rifle is a Win M70 Varmint 1-14 twist. I'm using Win brass and Fed GM210M (Match) primers, OAL 2.812". Hodgdon's data is pretty conservative in my experience with my rifle, so I'll share what I found (10) shot groups.
42.0 gr = 3852 fps avg, ES 49, SD 23, 42.2 gr = 3853 avg, ES 73, SD 31, 42.4 gr = 3869 fps avg, ES 90, SD 36, 42.6 gr = 3875 fps avg, ES 31, SD 12, (best group .296")
RL16 and same components above:
40.7 gr = 3746 avg, ES 16, SD 11, 41.1 gr = 3821 fps avg, ES 8.6, SD 6, 41.5 gr = 3896 fps avg, ES 1, SD 0.7, 41.9 gr = 3906 fps avg, ES 15, SD 11
41.5 - 41.7 grains gave me the best accuracy. The 41.7 load averaged at 3908 fps, nothing much to gain after this weight of powder in my rifle.
All of my testing with H4350 and RL16 with bullets less than 55 grains indicated to me it was slightly too slow for optimum results.
Reloader 15.5 has shown lots of promise with 50 grain bullets in my rifle. Using the Sierra 50 grain BlitzKing at 2.735" OAL.
38.4 gr = 3857 fps avg, ES 52, SD 36, 38.8 gr = 3906 fps, ES 7, SD 4.5, 39.2 = no velocity data due to limits of LabRadar Chrono but I had the best group at .360" @ 100 yds.
Later in September a 40 grain load same bullet and length 40 gr = 3997 fps avg, ES 23, SD 11 for a .492" group, and 40.4 gr = 4044 fps avg, ES 20, SD 9 for a .452" group.