Not with the lots of powder I've been getting and in my rifles. All my measurements are precise, and I still have to Jack with powder Ba to bring velocity in with charge weight. Now once I do that, it's accurate.
For example, if I were to use a QL load without first working it up in my rifle with the powder I'm using, H1000 for example, it'll tell me 77 gr is a safe load, when in fact, it is 2 gr over pressure in my rifle. And not just that rifle, lot of powder, lot of bullet, or lot of case, either.
Maybe there is a "trick" I am missing, I definitely do not profess to know everything about the program, I just know how to safely use it for my purposes and within my capabilities.
But that doesn't help the OP.
He's looking to confirm the viability of RL33 with his Weatherby.