I think you get the point that estimating wind at long range is very difficult, especially when hunting.
The best is to scope out an area you are hunting and flag branches and stuff. That way you can get some visible reference. Also looking at trees, grass, etc. will help. Practise shooting into that area as much as possible.
Now if this is a new area, you will have to rely on all the experience you gained shooting. When you have made your best guess, take a windage shot at something at the same distance as your game, but off to the side 200 to 300yds so the sound of the impact does not scare off your game. If you have estimated correctly, go for your game. If not, you should be able to compensate and engage your game.
The noise of a gunshot does not seem to bother game too much when it is that far away. However, whacking a rock near your target is sure to send them running. If you are shooting in terrain where you cannot see your windage impact, move closer to "sure" thing range. Hail Mary's are not going to make you very popular.
Know when not to pull the trigger.
Good luck...
Jerry