.25-06 100 Gr Barnes TTSX at 3225.
Two goats two weeks ago, first at 289, DRT she was laying on a hillside across a wide draw, broke both front legs and smashed the heart, second at 410 double lung slightly higher than I like, ran about 400 yards FAST then died on the flat about 100 yards off the road... easy drag!
Neither one of mine was tough, actually more tender than the Texas Whitetails I regularly shoot. They made fine sausage!
As far as wind goes learn to read the wind to estimate fairly close and learn your ballistics tables including wind drift. Buy a good scope with target type turrets for quick adjustments. Adjust for wind and elevation, then hold dead on.
The 289 was my second longest shot ever and it was in a 10 mph left to right wind. thankfully the 410 shot was on a calm day and was my longest shot to date. I look forward to more!