If no further than 400 yards I use 60 grains of RL-17 WW brass Fed 210 primer and a Barnes 150 gr TTSX. Opens on deer, will hold together on Moose and Elk and shoots nice groups, oh ya almost 3100 fps out of a 24 inch Remington Barrel doesnt hurt either. As always this load is safe in my rifle, reduce by 10% and start from there.