Much depends on which 75g HP you have as there is a lot of difference between a Sierra and Hornady Hp. I had a 75g Speer hp blow up on a hip joint of a coyote, so those became chuck and jackrabbit bullets.
All of these bullets like to be seated close to the lands, so you have a catch-22. Chances are, that the barrel has some wear on it being a 10 twist with the leade being as long as it is. You may be close to the end of the barrel's life. In this case, other bullets with more bearing surface will shoot better in a long, worn throat.
75g Sierras will shoot well with some jump. Another option of course is to sell the bullets and buy the 85g Sierra spt that is a flat base with some bearing surface. 90g Speer is another option, and any 100g flat base should shoot very, very well. In my well worn Rem 700, I have to shoot a 95g SST, and it does a job near and far, coyotes to deer.
With the 75g Sierra's, IMR 4064 with a federal 210 has served me well over the years on coyotes up to and including the 80g bullets. I then went to Win 760 or 4350 for the heavier bullets.
If you are using the rifle as a repeater, I would want .100 of bullet in the case.
243 Winchesters are NOT easy on throats.
Good luck!