I've had many Weatherby rifles over the past 45 years.... Of all those rifles some of which I still have; the 257 Wby Mags was my favorite. I believe the most accurate was the 26" inch {a must barrel length} MK V Accumark, hands down. I was never that happy with the Vanguards I bought, there nice rifles but not a Mark V.
I think Roy Weatherby caliber of choice was the .257 Wby Mag.
I shot both Deer and Elk with the .257 Wby Mags, not too mention a few Yotes one at perhaps the longest distance I ever shot one.
My bullet of choice was the 100gr blue coated Barnes for everything.
Good luck
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Thanks! I am sure that my first Weatherby will be in the not too distant future! I'm going to go with an Accumark LH 257!!