Ok guys, great responses and stories. Thanks for all the good stuff. I did a quick count, counting multiple votes by the same person as full votes, i.e. if you said 243, 6.5 Creedmoor and 30-06 are all great, I gave all three a vote. I also tried to eliminate the same person voting twice for the same cartridge:
243: 25 votes
6.5 Creedmoor: 13
25-06: 13
260 Rem: 9
270 Win: 7
30-06: 6
7mm-08: 5
30-30: 4
6 mm Rem: 4
257 Roberts: 4
Also there were a number who said essentially no such thing as best, stupid question, or the 243 is like Nickelback: 8 votes. I got a kick out of those, especially the Nickelback and the creedmoor man bun, blue eyes/chaps, etc. Haha all good fun.
Plus there were a few side conversations which always entertain and add variety but did not count in the votes.
Lots of honorable mentions (1-3 votes):
222 Rem, 6.5x284, 6.5 PRC, 250 Savage, 257 Weatherby, 308, 7mm Rem mag, 6mm Weatherby, 6.5-06, 338 Federal, 32 Win Special, 300 Win Mag, 280 Rem AI and 375 H&H.
No offense intended if I missed your vote and left it off the list.