I shot my moose last year with one, hunted the whole time with it on. Had electrical tape over the muzzle. Worked fine, killed a moose at 10 yards with it. But I shoot this rifle suppressed pretty much exclusively,
My take is if you typically shoot the rifle with one, then hunting would be no issue. But of the flip side. I love shooting my sheep gun suppressed, but stopped doing it, because I won't ever hunt with it on. Just a weight thing...want my load workup and data to be in the configuration I will hunt with it.
Gun above was a 300wsm
I hunt suppressed with 223, 6-47 lapua, 6.5-284, 7-300weatherby and 338 norma. I use tbac suppressors. Weight is detrimental if you hike far, but the animals spook less. A good friend shot a bull elk at around 500 yards last year from a herd of about 20 animals with a suppressed 7-300. The elk didn't go down right away so he put a second shot into it. The herd did not spook which I think kept the bull from running at the first shot. For most of my hunting I don't load the rifle or screw on the suppressor until I'm setting up for a shot.
I will eventually get a Ultra 7 or 9, which ever one I can find first. Ive heard nothing but good things. I know some people shoot the 5. I would think that is a good middle ground for weight and sound.