I have been shooting mostly Berger hunting bullets on big game. They have got it done for me. Only 1 exited, and that was a quartering toward shot, but they make a mess of the organs.
I have seen the results first hand on 4 cow elk and 2 mulies. None made it more than 40 yards. With the results, I will take the no exit. I would not shoulder shoot animals on purpose with Bergers on cow elk or larger.