Energy is velocity squared time weight divided by 450240 = Ken Energy.
It does not take into account of bullet construction, expansion and shot placement.
You can have a super velocity X gr bullet that passes trough the critter with no expansion and have a wounded animal running around the mountains and the bullet flys on carrying its wasted energy to no man's land.
Or you can have a moderate velocity bullet, med weight, hitting the lungs and expanding to do massive damage to the lungs, and stop before it exits the animal, often stopping just under the skin on the far side of the animal, thus expanding its energy totally in the animal.
Or you can have a bullet that expands, destroying the lungs, passing through the animal leaving a large exit wound to assist the animal in bleeding out. Yet some of the energy is wasted because this bullet too, flys off with wasted un-used energy.
In short, in my opinion, I don't pay attention to energy numbers, I want a bullet to expand doing the most damage to the heart and lung are, its nice it if exits leaving a exit wound but I wont loose any sleep if the bullet destroys the heart and lungs and doesn't exit. As long as it penetrates enough to destroy the vitals.
The bullet also needs to have enough mass to blow through a shoulder and still destroy the heart lung area.
Shot placement is the most critical.
Think of energy as heat. I fire in a stove on a cold winter day puts out energy (heat) and its well used while you set in front of in drinking your morning coffee. That same fire would be useless setting out in an open field. Yes it still had energy (heat) but its not doing you any good.
So as said, my opinion is to ignore energy tables, find a bullet and drive it fast enough that you get good expansion and penetration need to do max damage to vitals and then put that bullet into the vitals.
Most people say you need between 1800-2000 ft lbs of KE for elk. Last year I shot this cow at 342 yards with a 270 using 150 Hor. IBs. it should have developed about 1500 lbs at that range. I don't know, I don't care. It destroyed the lungs, and exited. No blood trail because all it did was roll down the hill into the creek. Yet according to some I didn't have near the KE I needed.
Maybe, maybe not, but I have the elk (had, I ate it)