I use a 100 yard zero for my target shooting just as a base line, then I dial everything out from there. When I go hunting I use 2 different loads. I have a long range load which I zero my turrets for at 100 yards, then I dial max point blank range for my short range load and don't worry about having to dial anything. I figure when the time comes for the long shot I will have the time to dial my turrets to zero, range the game, read the weather conditions, get a good rest etc. If I can't do all this I will not be taking a long range shot any way. As well, if I jump game while hunting I don't want to be worried about dialing the range in, just point and know I will hit. I use a 6" mpbr.