what game will you be hunting and how far? I have worked up loads for my 300 RUM all the way from the 125g BT to the 220g SMK. I used H-1000 for my powder of choice and have been quite happy. My favorite load is 92g H-1000, 200g AB, Fed 215, 3.660". Good for 3100fps and 1/2 MOA to 800 yards most the time. A good whitetail load I had worked up around the 150g CTBT. IT was 105g of H-1000, Fed 215, 3.660", 3650fps, and usually better accuracy than my 200g load, even out to 800 yards. For A coyote load you could not go wrong with the 125g BT at 3950fps. It will vaporize a milk jug at 100 yards, imagine what it would do to a yote????