JMO, but after 4 trips I highly recommend buying the book "Perfect Shot Africa" by Dr Kevin Robertson. Full of excellent info on cartridges, game, where to shoot, etc. Talk to your PH about cartridge recommendations. Standard cartridges, 308, 30-06, 7mm REM Mag, 300 WM, etc are much easier to find there if your ammo box disappears. I took a 300 WM my first trip, then came home and bought a 375 H&H for one gun safaris. It served me well from duiker to Cape buffalo using Barnes bullets (several PHes recommended). In between were lions, eland, sable, warthogs, kudu, zebra (everyone needs a zebra rug!) and many more fun stalks.
Practice standing off sticks. The way it goes is you will be following your tracker and PH by a couple of steps. They spot the game and set up the sticks. You move up resting your rifle on the sticks aim and shoot. Immediately reload and prepare for a follow-up whether the game is down or not. This is all in less than 10 seconds, so practice by setting up your sticks, sling your rifle and step back a couple of steps. Then the count starts.
Warning! Africa is highly addictive! My plan was to return every time I got the funds together, but the Covid hit followed by old man health issues. Now Africa is just another fleeting dream.
I am envious of your trip! Wishing you a great hunt!