Move up to a 243 for those heavier bullits and you will find plenty of ammo choices. I shoot alot of 22-250 Hornady V-max 55gr and I have killed Deer, although I don't recommend it for Deer hunting, Fox, and Ground Hogs and it's a devestating round. So I don't know what you are trying to kill but the 22-250 is an awsome rd.