I have a hard time understanding how someone can't figure a 22-250 won't clean a deer's clock, maybe I've just shot to many deer and antelope with one, maybe people just don't know they make bullets in 22 cal that are not varmint bullets but bullets like corelocks, partitions and many other soft point, I typically shoot them right behind the shoulder and they run 30-50 yards and tip over, just like when I shoot them with my 250-3000, 243, 6.5 Creed or 270 WSM but with less recoil, heck I've had deer make it farther shot behind the shoulder with a RUM than I have a 22-250!!