When I was running them, I only had opportunity for deer. It's been 5 years since I've been drawn for elk. Most of my shots were in the crease just behind the shoulder. Never had a lick of trouble with them, deer at 200 yards and under running them out the muzzle right at 3000 fps in my 300 win mag, and 2750 out of my 30-06, so pretty hot loads. They would punch right through with caliber size entry and golf ball size exit, usually with a good quantity of lung and rib bone.
Every animal was DRT. Suspect with impact velocities in the 2500-2600 FPS range, the animal succumbed to hydrostatic shock and bled out right on the spot in his sleep.
Now, my cousin had issues with them in 7 Mag, and he quit using them after 1 elk hunt. 4 shots on the animal before he anchored him.
I've since moved on to the 208 ELDM and the 215 BHT. My rifles seem to like the 208 the best.
I do still have some 200 gr ELDX loaded up for 308, 30-06 and a few in 300.
They definitely would not be my first choice for bear. I'd rather have something in the 338-375 caliber for them, preferably with a proven performer on dangerous game.