I have used IMR 4320 with 125 grain bullets in a 30-06, it is one of the most accurate loads I have tested, I also use IMR 4320 in a 300 Savage and is the powder I use for a 225 grain bullet in my 338-06 AI. I have used IMR 4350 in various calibers over the years and was the first powder I started loading with in my 30-06 over 50 years ago. I haven't used IMR 4227 much but I started with it in a 22 Hornet years ago and have loaded it in a. 410 shotgun. I will add that IMR 4350 is in my opinion one of the most versatile powders you can use and is very accurate in 30-06, .270 Winchester, 300 Magnums, as well as some smaller calibers such as. 243 Winchester.