I've shot wild pigs in Arkansas with a .375 Ruger... I understand. It was more of a test for the bullet I loaded than fear of the pig not dying easily. (Although I did have a 650lb boar in the Cumberlands look at me without flinching and start to sprint requiring a follow up and almost a 3rd - shot his heart out on the first shot - using a 7 SAUM with 175gr Partitions). I've found good 6mm bullets going really fast (3350+) and 6.5 - 6.8mm bullets that expand rapidly shot at any velocity from 2700 - 3300 put down whitetail and mule deer for me faster than anything else. Bigger calibers kill, but there's usually a blood trail, and smaller, slower calibers kill, though not as dramatically.
I'm thinking LeverEvolution, Power Pro 2000, H380, H414, Big Game, N540, and as high as RL 16 or as low as 203B are going to be the superstars of the loading endeavor.