Reaching out with good power at distance will be hard to do and not blow them up, on close shots. But I would look at 22creedmoor, 243ai, 22-243ai or standard, 6creed also. Do you have a budget and weight for the rifle lots of things to think about. I built my first custom coyote rifle as a 22-243, heavier barrel threaded for a can and used a Boyd's stock. Well that build came in ready to hunt at 15lbs, so now I am doing a new one hoping to be in at 10lbs or under. Have carbon stock, carbon barrel from Pederson LLC, big horn action.